Celastrol (celastracaea) is an element that comes from trees and shrubs, the Medical College of Georgia is studying this anti-inflammatory plant in terms of cancer treatments and inactivating a required protein for cancer growth. It has been used for centuries in China to treat chills, fevers, joint pain, inflammation, and more. Dr. Ahmed Chadli is a biochemist in the MCG Center for Molecular Chaperones/Radiobiology and Cancer Virology, he says "Cancer cells need HSP90 more than normal cells because cancer cells have thousands of mutations. They need chaperones all the time to keep their mutated proteins active. By taking heat shock proteins away from cells, the stabilization is taken away and cell death occurs." Scientists are seeing the potential in regulating HSP90. They are hoping in a therapy type setting it can reduce the probability of cancer resistance.
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