Tuesday, December 1, 2009

Research Sheds Light on Workings of Anti-Cancer Drug

A copper drug called tetrathiomolybdate (TM) has been shown to be effective in the treatment of Wilson Disease. Wilson disease is caused by an overload of copper and mestastic cancers which spread through the body. a study at Northwestern University. The structure consists of TM combined with copper chaperone proteins. "Based on the structure and additional experiments, the scientists propose that the drug inhibits the traffic of copper within the cell because of its ability to sequester copper chaperones and their cargo in clusters, rendering the copper inactive." The inorganic elements such as zine, copper, and iron are benficial to the function of cells but too much can be harmful for the body, the bodies inability to dispose of the extra copper can lead to liver problems, which is a mjor cause of Wilson Disease.
http://www.sciencedaily.com/releases/2009/11/091126173033.htm

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