A naturally produced molecule called resveratrol, found in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain. This even worked while eating a high fat diet resveratrol helped to prevent diabetes.
When acting directly on certain proteins in the brain, resveratrol may offer some protection against diabetes.
Insulin levels in the mice given resveratrol, actually started to drop and were halfway to normal by the end of the five-week study period, even though the animals remained on a high-fat diet.
By knowing that the central nervous system is involved, pharmaceutical companies can begin to focus on developing drugs that sirtuins the brain.
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