Showing posts with label brain. Show all posts
Showing posts with label brain. Show all posts

Thursday, August 4, 2016

Red Blood Cells can Sense Low Oxygen Levels in the Brain

A study done at the University of Rochester Medical center has shown evidence that red blood cells can sense and monitor oxygen levels within the brain. Once the red blood cells pick up this sense they can spring into action and rush into brain. Researchers tested this out on mice by depleting the oxygen supply to the brain and recording the increase in the blood flow of the red blood cells through the capillaries. This finding emphasizes the importance and large effect that blood has on the brain. In all the results will also help shed light on how interferences with blood flow to the brain can cause brain disorders.
Above is artificial capillaries in which red blood cells are flowing through. The cells are able to squeeze through the capillary much faster when there is low levels of oxygen. When there is high levels of oxygen the cells stiffen and are not as flexible to flow through the capillaries as quickly.

Saturday, July 23, 2016

Bird Brains Have as many Neurons as Primates

Birds are far more intelligent and impressive creatures than some may realize. Even with small brains birds are capable of making complex cognitive decisions and actions. How is this possible? These avian creatures have a high neuron density. Though the brain is small the amount of neurons is near that of a mid sized primate. The study comes from universities out of Austria, Czech Republic, and Brazil. It was one of the first studies of its kind in the methods used to calculate the amount of neurons. Over twenty different species were sampled and brains dissected. The findings of the study were overall expected in the science community. As such, behaviors like tool building found in crows, and majestical vocal abilities found within songbirds, require higher cognitive function.





Monday, August 3, 2015

Diabetes Takes a Toll on the Brain

Many of us are acquainted with one or more people who suffer from some level of diabetes.  Therefore we are all familiar, to some degree, with the toll it can have on the human body.  One of the most common forms of diabetes is Type 2 diabetes.  Research has indicated that Type 2 impairs blood flow to the brain and, as a result, leads to a sharper decline in mental awareness over time.  The cognitive ability of 40 subjects of about 66 years was put to the test; half of the group was diagnosed with diabetes, the other 20 were the control.  They completed an initial set of tests, and then a set of follow up tests two years later to determine any possible cognitive decline correlated with the presence of the disease.   It seemed that at the end of the period, the subjects known to have diabetes showed a greater decline in gray matter volume, mental test scores, and blood flow in the brain. 



The researchers found a positive correlation between blood flow to the brain and test scores.  The subjects that were diagnosed with diabetes suffered from a lower rate of blood flow, and therefore had a more difficult time scoring on the cognitive tests.  The findings of this investigation, at face value, are an important find.  The test should be repeated, however, to eliminate external pressures on the results.  Nonetheless, it is an important starting point to understanding the many side affects diabetes can have on us or our loved ones.

Wednesday, December 5, 2012

Origin of Intelligence and mental illness linked to ancient genetic accident

                                                     
Hopefully we have all seen the Teenage Mutant Ninja Turtle, well in the movie they describe how they became mutant. The baby turtles were swimming in primordial ooze that caused a genetic mutation that not only made them human size but also made them more intelligent! Well Professor Seth Grant of the University of Endinburgh led a group of researchers, that discovered for the first time how humans and other mammals have evolved to have intelligence. They have identified that 500 million years ago when the genes that enable us to think and reason evolved. This research is detailed in two papers in Nature Neuroscience, the papers also shows a direct link between the evolution of behavior and the origins of brain diseases. The study shows that the intelligence we possess developed as a result of an increase in the number of brain genes in our evolutionary ancestors. The researchers suggest that a simple invertebrate animal living in the sea 500 million years ago experienced a "genetic accident" that resulted in extra copies of these genes. This animals decendents (humans) greatly benefited from these extra genes. The researchers studied the mental abilities of mice and humans using comparative tests. They then combined their results to information from the genetic codes of various species to work out when different behaviors evolved. They found that higher mental function in the humans and mice were controlled by the same genes. The study also showed these genes were mutated or damaged. Professor Grant concluded that, "The researchers previously shown that more then 100 childhood and adult brain diseases are caused by gene mutations. It would be interesting to see if this is all true or not! http://esciencenews.com/articles/2012/12/03/origin.intelligence.and.mental.illness.linked.ancient.genetic.accident

Thursday, December 15, 2011

Tireless research reveals secrets of the 'sleep hormone'




This article may be the answer for anyone out there suffering from insomnia! A team from the Research Institute of the McGill University Health Centre (RI-MUHC) and McGill University has made a discovery by revealing the work of melatonin, also known as the "sleep hormone." The research, which was worked on with the help of scientists in Italy, shows the role played by the melatonin receptor in the brain that promotes deep sleep. This discovery led the researchers to develop a new drug called UCM765 which will activates this receptor. The results may be the development of new and promising treatments for insomnia, which is a sleep disorder millions of people suffer from.

Monday, November 7, 2011

Brain Parasite That Directly Alters Brain Chemistry


After reading a multitude of articles I found this one to be the most intriguing because the brain is the most important part of the human body and I found any and all information on it to just be simply amazing. According to the article it explains how there is a parasite that has been find in mammals that can affect the dopamine levels. So far the work has only been done and tested on rodents it is believed by Dr. Glenn McConkey that these findings can inevitably help by shedding new light onto treating human neurological disorders that are considered to be dopamine related. An example of which commonly known is schizophrenia. The research is hopeful to figure out how and why these parasites can manipulate the brain. For more information on dopamine click here. Hopefully researchers can discover more about this parasite and figure out how to treat the dopamine related disorders that correlate with it.

Friday, July 29, 2011

Studying Brain Activity From Decapitations


An article on MSNBC suggests that the brain may live on after being decapitated for a period of time. A study done at Raboud University Nijmegan in the Netherlands explored the ethics of killing lab rats through decapitation. The EEG ( a measure of electrical brain activity), ended 17 seconds after decapitation. About a minute after, a large wave went through the brain. Dubbed the "wave of death", the researchers thought this was the final blow. Neurologist Michel van Putten and his colleagues at the University of Twente have suggested that the brain cells could be revived if fed oxygen and glucose. Granted, this is not a "living" brain, but is a very interesting fact about brain cells.
This article was interesting because of the strange nature of the study. Decapitation is a gruesome way to obtain information about brain activity, but nonetheless has given some interesting data on brain cells. This type of research could be very useful if it further gives information on the revival of brain cells. The medical field especially could benefit.

Photo: http://www.binauralbeatsonline.com/wp-content/uploads/2010/01/Brain-Waves.jpg

When the Brain Remembers but the Patient Doesn’t


This article from Science Daily discusses how the unconscious brain is able to function without the availability of the conscious brain. In one case, a patient survived an accident with brain damage and face blindness. To test her unconscious brain, doctors showed her images of familiar faces, unknown faces, and celebrity faces. They included new celebrities, as well as those who were famous before the patient’s accident.

The patient was not able to recognize the famous faces, however, her brain responded to the celebrities from before her accident. Professor Pegna concludes, “implicit processing might continue to occur despite the presence of an apparent impairment in conscious processing.” As long as a person’s cerebral structures are in a certain order (regarding time), then he will be able to respond to visual stimuli.

I think it is amazing how a person’s memory—from the time of the accident and beyond—may be damaged, but the memories that were established prior to the accident are still in tact. We can see here that just because a person with brain damage may not outwardly communicate visual awareness to doctors does not mean the brain is unresponsive. Ultimately, we can learn how important physiological testing is to learning about the condition of the brain.

Photograph: http://www.molwick.com/en/brain/025-human-brain-structure.html

Friday, July 15, 2011

Meditation for the brain

      An article recently featured on Science Daily discusses the benefits meditation have on the brain. Two years ago, researchers at UCLA found that specific regions in the brains of long-term meditators were larger and had more gray matter than the brains of individuals in a control group. This suggested that meditation may indeed be good for all of us since, alas, our brains shrink naturally with age. A follow-up study suggests that people who meditate also have stronger connections between brain regions and show less age-related brain atrophy. Having stronger connections influences the ability to rapidly relay electrical signals in the brain. And significantly, these effects are evident throughout the entire brain, not just in specific areas. Meditation appears to be a powerful mental exercise with the potential to change the physical structure of the brain at large. Collecting evidence that active, frequent and regular meditation practices cause alterations of white-matter fiber tracts that are profound and sustainable may become relevant for patient populations suffering from axonal demyelination and white-matter atrophy.

      I myself have never meditated. I know many people who regularly meditate and tell me I have to try it. My mom recently got into meditated. I've noticed a huge change in her mood and general outlook on things. She is a lot more relaxed than she used to be. Meditation always seemed like a waste of time to me but the more I read up on it the more I'm considering trying it
 


Computers and Our Memory


According to the New York Times, a recent study suggests that the internet and technology have significant effects on human memory. Scientists, led by Betsy Sparrow of Columbia University, conducted experiments testing the effect of technology on human memory. One test had participants type 40 pieces of trivia into a computer. They led half of the participants to believe that the trivia would be saved and the other half to believe that the trivia would be deleted. They found that the participants were a lot more likely to remember the trivia if they thought it would be deleted. Another test examined how computers affect what exactly we remember. The subjects were asked to remember specific facts and which of five folders on the computer they were saved in. The researchers found that the test subjects remembered the folder instead of the fact.

The experiment dives into what is called transactive memory. This theory suggests that people rely on other people and reference materials to store information instead of trying to remember this information themselves. Dr. Sparrow concluded that the Internet has become the number one source for external storage of information.

This article was interesting because technology and the age of the internet has taken over the world. There is no shortage of how and when we can retrieve information. This article raises some significant points. Are we becoming too dependent on technology to store information? Can this, in the long term, affect humans negatively? For all the advantages of the internet and computers, there are still some questions that linger.


PHOTO: http://hplusmagazine.com/sites/default/files/images/articles/mar10/man-inserting-memory-card-in-brain.jpg

Thursday, July 7, 2011

Lactate From Astrocytes May Play Large Role in Long-Term Memory


What where once thought to be little more than structures to fill the gaps between important neurons, may play a more important role than just that. Recent studies have suggested that these star shaped cells in our brains called astrocytes, are involved in information processing, signal transmission, and help to regulate neurons and synapses. Also they are responsible for long-term memory formation.

Lactate from astrocytes into neurons is what long-term memories are dependent on. When that transfer of lactate in to neurons is blocked in any way, lab rats fail to remember what happened days or weeks ago, with short term memories being unaffected. The way the scientists tested this idea in rats was rather simple. By exposing rats to a single unpleasant experience, particularly a foot shock, they form a lasting memory of where the unpleasant experience occurred and avoid it. Then, when disrupting the lactate transporters on the astrocytes or neurons the rats developed amnesia.

These are important findings that in the future, may help us better understand neurodegenerative diseases such as Parkinson’s or just the memory loss associated with old age. Synaptic function loss between neurons and the astrocytes seem to be the main cause of long-term memory loss. More studies and experiments on the synapses between the neurons and astrocytes may help us form remedies that will help us retain our long-term memories before we lose them.

Thursday, May 5, 2011

Turning 'Bad' Fat into 'Good' Fat

More than two-thirds of adults in the United States are overweight, and more than one-third are obese, according to government estimates.

According to ScienceDaily, by knocking down the expression of a protein in rat brains known to stimulate eating, Johns Hopkins researchers say they not only reduced the animals' calorie intake and weight, but also transformed their fat into a type that burns off more energy. The finding could lead to better obesity treatments for humans, the scientists report.

"If we could get the human body to turn 'bad fat' into 'good fat' that burns calories instead of storing them, we could add a serious new tool to tackle the obesity epidemic in the United States," says study leader Sheng Bi, M.D., an associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine.

The Johns Hopkins study, published in the journal Cell Metabolism, looks at two types of fat made by the body: white and brown adipose tissue. White fat is the typical fat that ends up around your middle and other places, and is the storehouse for the extra calories we eat. White fat cells have a single large droplet of lipid, one of fat's building blocks, such as cholesterol and triglycerides.

Bi and his colleagues designed an experiment to see if suppressing the appetite-stimulating neuropeptide Y (NPY) protein in the dorsomedial hypothalamus of the brain would decrease body fat in rats. Located just above the brain stem, the hypothalamus helps regulate thirst, hunger, body temperature, water balance and blood pressure.

For five weeks, two groups of rats were fed a regular diet, with one group also treated with a virus to inhibit NPY expression and the other left as a control group. At the end of five weeks, the treated group weighed less than the control group, demonstrating that suppression of NPY reduced eating.

Then, researchers split each of the groups into two, creating four sets of rats. One of the treated groups of rats and one of the control groups were fed a regular diet while the other treated and control groups got a high-fat diet. Of the rats on the regular diet, the control group weighed more at the end of 11 weeks than those rats in which hypothalamic NPY expression was knocked down. In the high-fat group, the control group rats became obese; those rats in which NPY expression was silenced gained less weight.

Bi says he believes that the transformation from white to brown fat resulting from NPY suppression may be due to activation of brown fat stem cells contained in white fat tissue. While brown fat seems to vanish in humans as they emerge from infancy, the brown fat stem cells may never disappear and may just become inactive as people age.

Bi says it may be possible to transplant or inject brown fat stem cells under the skin to burn white fat and stimulate weight loss. "Only future research will tell us if that is possible," he says. This study also shows that low levels of hypothalamic NPY increase spontaneous physical activity, improve blood sugar levels and enhance insulin sensitivity in rats, but it remains undetermined whether this brown fat transformation also contributes to these effects.

I found this article to extremely interesting. You cannot go a day without hearing about obesity on the news. I feel that this research can lead to a better, more natural way to help those who are obese lose weight.

Wednesday, February 23, 2011

Cell Phones may Affect Brain Metabolism


An article was published February 22nd, 2011 by Laura Sanders about how a 50 minute call may boost brain activity in regions where the phone is located. Researchers did a study, that shows that after just a few minutes of a call a PET scan revealed that brain regions next to the phone caused higher levels of glucose metabolism. "The human brain is sensitive to electromagnetic radiation that is emitted from cell phones" says coauthor Nora Volkow of the National Institute of Drug Abuse. Brain regions affected change depending on the phone design and how people hold it. Researchers dont know yet if radiation from a phone stimulating the brain is dangerous but this is a significant finding. The reason i found this article interesting was because it shows how cell phones can be affective of the brain and hopefully in the future cell phones will be created that do not stimulate the brain and is safer to talk for long periods of time. http://www.sciencenews.org/view/generic/id/70134/title/Cell_phones_may_affect_brain_metabolism

Saturday, May 8, 2010

Even silent videos excite the listening brain

Have you ever peered through a window at a sight that, from your experiences, holds the expectations of making a certain sound, and causing, within you, a certain reaction for that matter. Kaspar Meyer, of the University of Southern California, and colleagues used a serious of tests to show that the human brain will react in the same way to a sight whether or not the expected sounds accompany it. After observing the brain activity of a few volunteers who looked at a series of video clips, including people playing violins, a dog howling and chainsaws cutting into trees, Meyers and his colleagues were then able to determine which of this clips other volunteers were watching based solely on their brain activity responses. This was possible because the tests showed patterns in brain activity among the test subjects based upon the particular clip in which they were watching.