Class of RNA molecules protects germ cells from damage

Biologists from the University of Pennsylvania School of Veterinary Medicine have come too a new theory on the human male's loss of fertility. These molecules called pachytene piwi-interacting RNAs, or piRNAs serve a protective role in the body's passing on of genes to offspring. Without these molecules germ cell development in males comes to an abrupt end. They protect by suppressing the activity of transposable elements or "jumping genes," which are stretches of DNA that can change position and cause potentially damaging genetic mutations. These sequences are also known as transposons. Lack of these certain cells can cause massive DNA damage.
"There are about 50 human diseases caused by transposable elements, so it's important for the body to have a way to try to repress them," Jeremy Wang said. Wang and his colleague authored the entire study and are experts in the field. In experiments with lab mice, in the presence of these germ cells lack of mature sperm was evident. The master role that these RNA cells serve are irreplaceable, and otherwise could lead too many health problems. This research was supported by the National Institutes of Health's National Institute of Child Health and Human Development. piRNA Article- ScienceDaily